The upsides of research ties between companies and universities are legendary. Silicon Valley, Route 128, Research Triangle, and their numerous superstar companies with academic roots are leading examples. Annual benefits are now measured in the billions of dollars, thousands of patents, and hundreds of start-up companies. But corporate bias is a known risk to scientific integrity. And as universities find themselves increasingly enticed by governmental budget cuts to court industry dollars, their eagerness for private-sector partners appears to be outpacing their willingness to set firm rules on ethical boundaries and to investigate when things go wrong.