Florida State University

The synthesis of Taxol by Florida State University Professor Robert A. Holton represents a landmark achievement in cancer treatment. Originally derived from the rare Pacific Yew tree, the drug’s production was limited until Holton’s team developed a semi-synthetic process in 1989. This breakthrough allowed for large-scale manufacturing via Bristol Myers Squibb, ultimately treating more than 1 million patients with breast and ovarian cancer. The partnership generated over $350 million in royalties for FSU, funding academic excellence and research. Holton, who achieved the first total synthesis in 1994, left a lasting impression in organic chemistry before his passing in 2025. Learn more